Augmentation of human thymocyte proliferative responses by retinoic acid.

  title={Augmentation of human thymocyte proliferative responses by retinoic acid.},
  author={Neil Sidell and Estela Famatiga and Sidney H. Golub},
  journal={Experimental cell biology},
  volume={49 5},
When 10(-5) to 10(-7) M all-trans retinoic acid (RA) was added to human thymocyte or tonsil lymphocyte cultures in the presence of mitogens or allogeneic stimulator cells, blastogenesis was increased up to 2.5-fold. No augmentation in proliferative responses of peripheral blood or spleen lymphocytes was observed. In the thymus, lymphocytes in the subclass of cells that did not bind peanut agglutinin (PNA) were responsible for the RA-induced enhancement. RA also increased the number of mitogen… CONTINUE READING

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