Augmentation of human immunodeficiency virus type 1 gene expression by tumor necrosis factor alpha.

@article{Okamoto1989AugmentationOH,
  title={Augmentation of human immunodeficiency virus type 1 gene expression by tumor necrosis factor alpha.},
  author={Takashi Okamoto and Toshifumi Matsuyama and Satoshi Mori and Yoshiaki Hamamoto and Nobuyuki Kobayashi and Naoki Yamamoto and Steven F. Josephs and Flossie Wong-Staal and Kunitada Shimotohno},
  journal={AIDS research and human retroviruses},
  year={1989},
  volume={5 2},
  pages={131-8}
}
It is now well established that cytokines are involved in the regulation of gene expression from HIV-1 LTR. The present study provides evidence that TNF-alpha stimulates HIV-1 gene expression and that the enhancer sequence within the HIV-1 LTR is involved in the stimulation. These results support the idea that immunologic stimulation and infection may trigger the development of clinical AIDS in individuals latently infected with HIV-1. 

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