Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

@article{Sathishkumar2016AugmentationOH,
  title={Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes},
  author={C. Sathishkumar and P. Prabu and M. Balakumar and R. Lenin and D. Prabhu and Ranjith Mohan Anjana and V. Mohan and M. Balasubramanyam},
  journal={Clinical Epigenetics},
  year={2016},
  volume={8}
}
  • C. Sathishkumar, P. Prabu, +5 authors M. Balasubramanyam
  • Published 2016
  • Medicine, Biology
  • Clinical Epigenetics
  • BackgroundA role of proinflammation has been implicated in the pathogenesis of diabetes, but the up-stream regulatory signals and molecular signatures are poorly understood. While histone modifications such as changes in histone deacetylase (HDAC) are emerging as novel epigenetic biomarkers, there is lack of studies to demonstrate their clinical relevance in diabetes. Therefore, we investigated the extent of HDAC machinery and inflammatory signals in peripheral blood mononuclear cells (PBMCs… CONTINUE READING
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