Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.

@article{Morishima2005AugmentationOE,
  title={Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.},
  author={Noriko Morishima and Toshiyuki Owaki and Masayuki Asakawa and Sadahiro Kamiya and Junichiro Mizuguchi and Takayuki Yoshimoto},
  journal={Journal of immunology},
  year={2005},
  volume={175 3},
  pages={
          1686-93
        }
}
IL-27 is a novel IL-12 family member that plays a role in the early regulation of Th1 initiation. We have recently demonstrated that IL-27 has a potent antitumor activity, which is mainly mediated through CD8+ T cells, and also has an adjuvant activity to induce epitope-specific CTL in vivo. In this study, we further investigated the in vitro effect of IL-27 on CD8+ T cells of mouse spleen cells. In a manner similar to CD4+ T cells, IL-27 activated STAT1, -2, -3, -4, and -5, and augmented the… CONTINUE READING
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