Augmentation of cell number and LAK activity in peripheral blood mononuclear cells activated with anti-CD3 and interleukin-2

@article{Anderson1988AugmentationOC,
  title={Augmentation of cell number and LAK activity in peripheral blood mononuclear cells activated with anti-CD3 and interleukin-2},
  author={Peter A.M. Anderson and Fritz Heintz Bach and Augusto Ochoa},
  journal={Cancer Immunology, Immunotherapy},
  year={1988},
  volume={27},
  pages={82-88}
}
A wide variety of human cancers currently have no effective treatment and are potential targets for lymphokine-activated killer (LAK) cellular immunotherapy. Relapsed acute lymphocytic leukemia (ALL) and neuroblastoma are two of the major therapeutic challenges in pediatric oncology today. However, one problem which makes LAK immunotherapy in children particularly difficult is obtaining the large numbers of cells required. Present adult therapeutic LAK protocols have utilized short-term (5 day… CONTINUE READING
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T cells and NK cells develop LAK activity in long term cultures with OKT3 + IL2

  • A Ochoa, DE Hasz, R Rezonzew, PM Anderson, FH Bach
  • 1988
2 Excerpts

The T cell antigen receptor complex expression in normal peripheral blood C D 4 CDS- T lymphocytes. A CD3 associated disulfide linked chain heterodimer

  • L Lanier, NA Federspeil, +4 authors A Weiss
  • J Exp Med
  • 1987

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