Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

@article{Kohout2001AugmentationOC,
  title={Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.},
  author={Trudy A. Kohout and Hiroyuki Takaoka and Patricia H. McDonald and Stephen J. Perry and Lan Mao and Robert J Lefkowitz and Howard A Rockman},
  journal={Circulation},
  year={2001},
  volume={104 20},
  pages={2485-91}
}
BACKGROUND Stimulation of beta(1)- and beta(2)-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta(3)AR is also expressed in the human heart and that its stimulation leads to negative inotropic effects. METHODS AND RESULTS To better understand the role of beta(3)ARs in cardiac function, we generated transgenic mice with cardiac-specific overexpression of 330 fmol/mg protein of the human beta(3)AR (TGbeta(3) mice). Hemodynamic… CONTINUE READING