Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist.

@article{Toyoda2005AugmentationOB,
  title={Augmentation of bone morphogenetic protein-induced bone mass by local delivery of a prostaglandin E EP4 receptor agonist.},
  author={Hiromitsu Toyoda and Hidetomi Terai and Ryuichi Sasaoka and Kazunori Oda and Kunio Takaoka},
  journal={Bone},
  year={2005},
  volume={37 4},
  pages={555-62}
}
Recombinant human bone morphogenetic protein (rhBMP) is viewed as a therapeutic cytokine because of its ability to induce bone. However, the high doses of rhBMP required for bone induction in humans remain a major hurdle for the therapeutic application of this protein. The development of a methodology that would effectively overcome the weak responsiveness to human BMP is highly desired. In the present study, we investigate the ability of a prostaglandin E EP4 receptor selective agonist (EP4A… CONTINUE READING

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