Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder.

  title={Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder.},
  author={Sabine Wilhelm and Ulrike Buhlmann and David F. Tolin and Suzanne A. Meunier and Godfrey D. Pearlson and Hannah E Reese and Paul A Cannistraro and Michael A. Jenike and Scott L. Rauch},
  journal={The American journal of psychiatry},
  volume={165 3},
  pages={335-41; quiz 409}
OBJECTIVE This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD). METHOD A randomized, double-blind, placebo-controlled trial investigating D-cycloserine versus placebo augmentation of behavior therapy was conducted in 23 OCD patients. Patients first underwent a diagnostic interview and pretreatment evaluation, followed by a psychoeducational… CONTINUE READING
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