Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2.

@article{Hank1990AugmentationOA,
  title={Augmentation of antibody dependent cell mediated cytotoxicity following in vivo therapy with recombinant interleukin 2.},
  author={Jacquelyn A. Hank and Rachel R. Robinson and Jean E. Surfus and Barbara M. Mueller and Ralph A. Reisfeld and Norman Kin Wai Cheung and Paul M. Sondel},
  journal={Cancer research},
  year={1990},
  volume={50 17},
  pages={5234-9}
}
Monoclonal antibodies (mAB) with tumor specificity are able to enhance the immunological specificity of interleukin 2 (IL-2)-activated lymphokine activated killer (LAK) cells. Antibodies may also be used to broaden the range of tumor types susceptible to immune mediated cytotoxicity by the activated LAK cells. In these studies, mAB with relative tumor specificity were used to target immunologically activated effector cells in an in vitro antibody dependent cell mediated cytotoxicity (ADCC… CONTINUE READING

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