Augmentation of allergic inflammation in prostanoid IP receptor deficient mice.

@article{Takahashi2002AugmentationOA,
  title={Augmentation of allergic inflammation in prostanoid IP receptor deficient mice.},
  author={Yoshimasa Takahashi and Shota Tokuoka and Taisei Masuda and Yousuke Hirano and Masafumi Nagao and Hiroyuki Tanaka and Naoki Inagaki and Shuh Narumiya and H. Nagai},
  journal={British journal of pharmacology},
  year={2002},
  volume={137 3},
  pages={315-22}
}
1 To evaluate the role of prostaglandin I(2) (PGI(2)) in allergic inflammation, allergic responses in the airway, skin and T cells were studied in mice lacking the receptor for PGI(2) (the prostanoid IP receptor) through gene disruption. 2 Three inhalations of antigen caused an increase in plasma extravasation, leukocyte accumulation and cytokine (interleukin (IL)-4 and IL-5) production in the airway of sensitized mice. These airway inflammatory responses were significantly greater in IP… CONTINUE READING