Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis

@article{Kaneko2000AugmentationOV,
  title={Augmentation of Vα14 Nkt Cell–Mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin a–Induced Hepatitis},
  author={Yoshikatsu Kaneko and Michishige Harada and Tetsu Kawano and Masakatsu Yamashita and Youichi Shibata and Fumitake Gejyo and Toshinori Nakayama and Masaru Taniguchi},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={105 - 114}
}
The administration of concanavalin A (Con A) induces a rapid severe injury of hepatocytes in mice. Although the Con A-induced hepatitis is considered to be an experimental model of human autoimmune hepatitis, the precise cellular and molecular mechanisms that induce hepatocyte injury remain unclear. Here, we demonstrate that Valpha14 NKT cells are required and sufficient for induction of this hepatitis. Moreover, interleukin (IL)-4 produced by Con A-activated Valpha14 NKT cells is found to play… CONTINUE READING

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SHOWING 1-10 OF 56 REFERENCES

Ant-tumor cytotoxicity mediated by ligandactivated human Va24 NKT cells

  • T. Kawano, T. Nakayama, +7 authors H. Endo
  • Cancer Res
  • 1999
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