Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor.

@article{Travers2008AugmentationOU,
  title={Augmentation of UVB radiation-mediated early gene expression by the epidermal platelet-activating factor receptor.},
  author={Jeffrey B Travers and Howard J. Edenberg and Qiwei Zhang and Mohammed Al-Hassani and Qiaofang Yi and Sulochanadevi Baskaran and Raymond L. Konger},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 2},
  pages={455-60}
}
UVB radiation (UVB) is a known inducer of many biological changes in human skin, and triggers the production of glycerophosphocholines that act as platelet-activating factor (PAF) agonists. To gain a better insight into the role of the epidermal PAF receptor (PAF-R) in UVB-mediated gene expression, Affymetrix oligonucleotide microarrays were used to compare mRNA expression in the PAF-R-negative epithelial cell line KB-expressing PAF-Rs (KBP) with that in KB cells transduced with a vector… CONTINUE READING

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