Augmentation of T-cell apoptosis by immunosuppressive agents.

  title={Augmentation of T-cell apoptosis by immunosuppressive agents.},
  author={Kyoichi Takahashi and Marleta Reynolds and Noriko Ogawa and Dan L. Longo and James Burdick},
  journal={Clinical transplantation},
  volume={18 Suppl 12},
The regulatory benefit of apoptosis (activation-induced cell death, AICD) in T cells can be influenced by immunosuppressive agents. We examined this for mycophenolate mofetile (MMF, using it's active metabolite, mycophenolate (MPA)) compared with rapamycin (RAPA) and the calcineurin inhibitors (CI) cyclosporin (CYA) and FK506 (FK). Pure T cells from peripheral blood leucocytes (PBL) were stimulated by anti-CD3 plus anti-CD28. Cell division (sequential cohort reduction in carboxyflourescein… CONTINUE READING