Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant

@inproceedings{Harper2016AugmentationOR,
  title={Augmentation of Recipient Adaptive Alloimmunity by Donor Passenger Lymphocytes within the Transplant},
  author={Ines G. Harper and Jason M Ali and Simon J. F. Harper and Elizabeth Wlodek and Jawaher Alsughayyir and Margaret C. Negus and Mahvash Saeed Qureshi and Reza Motalleb-Zadeh and Kourosh Saeb-Parsy and Eleanor Mary Bolton and J Andrew Bradley and Menna Clatworthy and Thomas M. Conlon and Gavin J. Pettigrew},
  booktitle={Cell reports},
  year={2016}
}
Chronic rejection of solid organ allografts remains the major cause of transplant failure. Donor-derived tissue-resident lymphocytes are transferred to the recipient during transplantation, but their impact on alloimmunity is unknown. Using mouse cardiac transplant models, we show that graft-versus-host recognition by passenger donor CD4 T cells markedly augments recipient cellular and humoral alloimmunity, resulting in more severe allograft vasculopathy and early graft failure. This… CONTINUE READING
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