Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18

@inproceedings{Hu2017AugmentationOA,
  title={Augmentation of Antitumor Immunity by Human and Mouse CAR T Cells Secreting IL-18},
  author={Biliang Hu and Jiangtao Ren and Yanping Luo and Brian Keith and Regina M. Young and John K. Scholler and Yangbing Zhao and Carl H June},
  booktitle={Cell reports},
  year={2017}
}
The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust enhancement of proliferation of IL-18-secreting human T cells occurred in a xenograft model, and this was dependent on TCR and IL-18R signaling. IL-18 augmented IFN-γ secretion and proliferation of T cells activated by the endogenous TCR. TCR-deficient, human IL-18-expressing CD19 CAR T cells exhibited enhanced… CONTINUE READING