Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex

@article{Huang2005AugmentationBC,
  title={Augmentation by citalopram of risperidone-induced monoamine release in rat prefrontal cortex},
  author={Mei Huang and Junji Ichiwaka and Zhu Li and Jin H Dai and Herbert Y Meltzer},
  journal={Psychopharmacology},
  year={2005},
  volume={185},
  pages={274-281}
}
A typical antipsychotics (APDs), e.g. olanzapine and risperidone, have been reported to be effective adjunctive treatment for depression if selective serotonin (5-HT) reuptake inhibitors (SSRIs) alone are ineffective. We utilized microdialysis in awake, freely moving rats to study the effect of risperidone in combination with citalopram, an SSRI, on extracellular 5-HT, dopamine (DA), and norepinephrine (NE) efflux in rat medial prefrontal cortex (mPFC). Risperidone (1.0 mg/kg, s.c.), given… CONTINUE READING