Auditory stimulation modulates CXCL12/CXCR4 expression in postnatal development of the newborn rat cochlea.

@article{Zhang2015AuditorySM,
  title={Auditory stimulation modulates CXCL12/CXCR4 expression in postnatal development of the newborn rat cochlea.},
  author={Wen Zhang and Fangjun Zhang and Yu Han and Hui Liu and Ye Wang and Bo Yue and Jun Chen and Yang Chen and Ya Gao},
  journal={Neuroreport},
  year={2015},
  volume={26 12},
  pages={681-7}
}
Sensorineural hearing loss is one of the most common sensory deficits. Recently, inner-ear stem cell therapy has been proposed for auditory afferent rehabilitation. CXCR4 is the primary physiologic receptor for CXC chemokine ligand 12 (CXCL12) and the CXCL12-CXCR4 pathway has been implicated in the process of migration, differentiation, and maturation of vertebrate neural stem cells. In this study, we examined changes in the auditory brainstem response and CXCL12/CXCR4 expression in newborn rat… CONTINUE READING
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