Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells.

@article{Bok2013AuditoryGS,
  title={Auditory ganglion source of Sonic hedgehog regulates timing of cell cycle exit and differentiation of mammalian cochlear hair cells.},
  author={Jinwoong Bok and Colleen Zenczak and Chan Ho Hwang and Doris K Wu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 34},
  pages={13869-74}
}
Neural precursor cells of the central nervous system undergo successive temporal waves of terminal division, each of which is soon followed by the onset of cell differentiation. The organ of Corti in the mammalian cochlea develops differently, such that precursors at the apex are the first to exit from the cell cycle but the last to begin differentiating as mechanosensory hair cells. Using a tissue-specific knockout approach in mice, we show that this unique temporal pattern of sensory cell… CONTINUE READING
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