Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in mice.

@article{Zhu2007AuditoryEF,
  title={Auditory efferent feedback system deficits precede age-related hearing loss: contralateral suppression of otoacoustic emissions in mice.},
  author={Xiaoxia Zhu and Olga N. Vasilyeva and Sora Park and Michael S. Jacobson and Joshua S. Romney and Marjorie S Waterman and David J. Tuttle and Robert D. Frisina},
  journal={The Journal of comparative neurology},
  year={2007},
  volume={503 5},
  pages={
          593-604
        }
}
The C57BL/6J mouse has been a useful model of presbycusis, as it displays an accelerated age-related peripheral hearing loss. The medial olivocochlear efferent feedback (MOC) system plays a role in suppressing cochlear outer hair cell (OHC) responses, particularly for background noise. Neurons of the MOC system are located in the superior olivary complex, particularly in the dorsomedial periolivary nucleus (DMPO) and in the ventral nucleus of the trapezoid body (VNTB). We previously discovered… CONTINUE READING
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