Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss

@article{Williamson2014AuditoryBG,
  title={Auditory brainstem gap responses start to decline in mice in middle age: a novel physiological biomarker for age-related hearing loss},
  author={Tanika T. Williamson and Xiaoxia Zhu and Joseph P. Walton and Robert D. Frisina},
  journal={Cell and Tissue Research},
  year={2014},
  volume={361},
  pages={359-369}
}
The auditory function of the CBA/CaJ mouse strain is normal during the early phases of life and gradually declines over its lifespan, much like human age-related hearing loss (ARHL) but within the “time frame” of a mouse life cycle. This pattern of ARHL is similar to that of most humans: difficult to diagnose clinically at its onset and currently not treatable medically. To address the challenge of early diagnosis, we use CBA mice to analyze the initial stages and functional onset biomarkers of… CONTINUE READING

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Auditory brainstem gap responses start to decline in mice in middle age : a novel physiological biomarker for age - related hearing loss

T. T. Williamson, J. P. Walton
  • 2014