Audiological findings in a Phase I protocol investigating the effect of WR 2721, high-dose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma.

@article{Rubin1995AudiologicalFI,
  title={Audiological findings in a Phase I protocol investigating the effect of WR 2721, high-dose cisplatin and radiation therapy in patients with locally advanced cervical carcinoma.},
  author={John S Rubin and Scott S Wadler and J J Beitler and Hilda Haynes and A. B. Rozenblit and Fiona M. McGill and Gary D Goldberg and Carolyn D. Runowicz},
  journal={The Journal of laryngology and otology},
  year={1995},
  volume={109 8},
  pages={744-7}
}
WR 2721 (ethiofos) protects against the toxic effects of the heavy metal compound cisplatin, which is used in the treatment of solid tumours. In a Phase I protocol designed to determine the maximum dose of WR 2721 which could be tolerated when administered in combination with cisplatin and radiation therapy to patients with cervical carcinoma, 11 patients were evaluated by audiologic testing before and after cisplatin WR 2721 administration in an attempt to identify the degree of ototoxicity… CONTINUE READING

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