Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.

@article{Frhwald2016AtypicalTT,
  title={Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.},
  author={Michael Christoph Fr{\"u}hwald and Jaclyn A Biegel and Franck Bourdeaut and Charles W. M. Roberts and Susan N. Chi},
  journal={Neuro-oncology},
  year={2016},
  volume={18 6},
  pages={764-78}
}
Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in SMARCB1 (INI1, SNF5, BAF47) or, to a lesser extent, SMARCA4 (BRG1) of the SWItch/sucrose nonfermentable chromatin remodeling complex. Recent transcription and methylation profiling studies suggest the existence of molecular subgroups. Thus, at the root of these seemingly enigmatic tumors lies a network of factors related to… CONTINUE READING
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