Atypical protein kinase Cs are the Ras effectors that mediate repression of myogenic satellite cell differentiation.

@article{Fedorov2002AtypicalPK,
  title={Atypical protein kinase Cs are the Ras effectors that mediate repression of myogenic satellite cell differentiation.},
  author={Yuri V. Fedorov and Nathan C. Jones and Bradley B Olwin},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 4},
  pages={1140-9}
}
Oncogenic Ha-Ras is a potent inhibitor of skeletal muscle cell differentiation, yet the Ras effector mediating this process remains unidentified. Here we demonstrate that the atypical protein kinases (aPKCs; lambda and/or zeta) are downstream Ras effectors responsible for Ras-dependent inhibition of myogenic differentiation in a satellite cell line. First, ectopic expression of Ha-RasG12V induces translocation of PKClambda from the cytosol to the nucleus, suggesting that aPKCs are activated by… CONTINUE READING