Atypical progressive supranuclear palsy with corticospinal tract degeneration.

  title={Atypical progressive supranuclear palsy with corticospinal tract degeneration.},
  author={Keith A. Josephs and O Katsuse and Dayne A Beccano-Kelly and Wen-lang Lin and Ryan J. Uitti and Yasuhiro Fujino and Bradley F. Boeve and Michael L. Hutton and Matthew C. Baker and Dennis W. Dickson},
  journal={Journal of neuropathology and experimental neurology},
  volume={65 4},
Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domain (4R tau). Corticospinal tract degeneration is not a common feature of 4R tauopathies. Our objective was to describe 12 cases with pathologic features similar to those of PSP but… CONTINUE READING
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