Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme.

@article{Everest2006AtypicalPP,
  title={Atypical prion protein in sheep brain collected during the British scrapie-surveillance programme.},
  author={Sally J. Everest and Leigh T Thorne and D A Barnicle and Jane C. Edwards and Hilary Elliott and Roy Jackman and James Hope},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 2},
  pages={471-7}
}
Scrapie of sheep and goats is the most common prion disease (or transmissible spongiform encephalopathy, TSE) of mammals and aggregates of abnormal, proteinase-resistant prion protein (PrP(Sc)) are found in all naturally occurring prion diseases. During active surveillance of British sheep for TSEs, 29 201 sheep brain stem samples were collected from abattoirs and analysed for the presence of PrP(Sc). Of these samples, 54 were found to be positive by using an ELISA screening test, but 28 of… CONTINUE READING