Atypical neuroleptic drugs downregulate dopamine sensitivity in rat cortical and striatal astrocytes.

@article{Reuss2001AtypicalND,
  title={Atypical neuroleptic drugs downregulate dopamine sensitivity in rat cortical and striatal astrocytes.},
  author={Bernhard Reuss and Klaus Unsicker},
  journal={Molecular and cellular neurosciences},
  year={2001},
  volume={18 2},
  pages={197-209}
}
Psychotic symptoms in different neuropsychiatric disorders are treated by neuroleptic drugs. Neuroleptics are known to block dopamine (DA) neurotransmission, however, cell types mediating their actions have not been determined. Recently, astrocytes have been demonstrated to express D1- and D2-DA receptors, whose activation leads to transient increases in intracellular calcium concentration. We show here that DA-sensitivity of cortical and striatal rat astroglial cultures, as monitored by… CONTINUE READING

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