Atypical inflammatory demyelinating syndromes of the CNS

@article{Hardy2016AtypicalID,
  title={Atypical inflammatory demyelinating syndromes of the CNS},
  author={Todd A Hardy and Stephen W Reddel and Michael Harry Barnett and Jacqueline A Palace and Brian G. Weinshenker},
  journal={The Lancet Neurology},
  year={2016},
  volume={15},
  pages={967-981}
}
Atypical Inflammatory Demyelinating Syndromes of the Central Nervous System
  • T. Hardy
  • Psychology, Medicine
    Contemporary Clinical Neuroscience
  • 2019
TLDR
The difficulties in diagnosing and distinguishing between conditions such as acute disseminated encephalomyelitis, tumefactive demyelination, Balo’s concentric sclerosis, Marburg's multiple sclerosis, and Schilder's diffuse myelinoclastic sclerosis are discussed.
Balo’s concentric lesions with concurrent features of Schilder’s disease in relapsing multiple sclerosis: neuropathological findings
TLDR
An autopsy case of middle-aged female with a chronic history of MS newly relapsed with atypical demyelinating lesions, which showed concurrent features of BCS and SD is described and the overlapping features between these two variants are discussed.
Pseudotumoral Demyelinating Lesions: A Presentation of Acute Disseminated Encephalomyelitis
TLDR
A 35-year-old male patient hospitalized in the department of neurology for a rapidly progressive onset of encephalopathy and polyfocal neurological deficits, with pseudotumoral lesions shown on brain MRI is presented.
Differential imaging of atypical demyelinating lesions of the central nervous system
TLDR
In this review, the main pattern of presentation of atypical inflammatory demyelinating diseases is discussed, with particular attention on the differential diagnosis and how to adequately define the correct etiology.
The spectrum of immune-mediated and inflammatory lesions of the brainstem
TLDR
Clinical features and MRI clues that help to distinguish among the different brainstem conditions are focused on.
Silent Tumefactive Demyelinating Lesions and Radiologically Isolated Syndrome
TLDR
A case involving an asymptomatic TDL detected incidentally during magnetic resonance imaging in an 18-year-old man, who was diagnosed with a radiologically isolated syndrome and did not develop any symptoms during the 1-year follow-up period.
Biomarkers in Rare Demyelinating Disease of the Central Nervous System
TLDR
Progress in biomarker research with respect to rare neuroinflammatory disease of the CNS is described, which may facilitate timely diagnosis and proper disease management, preventing disease exacerbation due to misdiagnosis and false treatment.
Description of a Tumefactive Demyelinating Lesion Studied with Advanced Magnetic Resonance Techniques: A Clinical Report and Review of Literature
TLDR
The case of a 17-years-old girl with a single TDL suddenly enlarging even under steroid therapy is reported, which poses a diagnostic challenge as it enlarged, showed areas of restricted diffusion and high perfusion.
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