Atypical functional properties of GluK3-containing kainate receptors.

@article{Perrais2009AtypicalFP,
  title={Atypical functional properties of GluK3-containing kainate receptors.},
  author={David Perrais and Françoise Coussen and Christophe Mulle},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 49},
  pages={15499-510}
}
The properties of synaptic receptors determine their mode of action at presynaptic and postsynaptic loci. Here, we investigated the atypical biophysical properties of GluK3-containing kainate receptors, which contribute to presynaptic facilitation at hippocampal mossy fiber synapses. We show, using fast glutamate applications on outside-out patches and kinetic modeling, that the low sensitivity of GluK3 receptors for glutamate is attributable to fast desensitization of partially bound receptors… CONTINUE READING

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Intersynaptic diffusion of neurotransmitter

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