Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers.

@article{Carcangiu2004AtypicalEP,
  title={Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers.},
  author={Maria Luisa Carcangiu and Paolo Radice and Siranoush Manoukian and Gianbattista Spatti and Morena Gobbo and Valeria Pensotti and Rosella Crucianelli and Barbara Pasini},
  journal={International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists},
  year={2004},
  volume={23 1},
  pages={35-40}
}
Although growing numbers of tubal carcinomas in carriers of BRCA1 and BRCA2 germline mutations have been reported, very little is known about the nature and frequency of their possible precursor lesions. The aim of this study is to investigate the occurrence of atypical proliferative tubal lesions in grossly normal fallopian tubes from 26 women with BRCA1 and BRCA2 germline mutations who underwent prophylactic salpingo-oophorectomy and whose ovaries were histologically negative for carcinoma… CONTINUE READING

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