Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone.

@article{DeLarge2017AtypicalBA,
  title={Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone.},
  author={Alyssa F DeLarge and Laura L Erwin and Peter John Winsauer},
  journal={Neuropharmacology},
  year={2017},
  volume={119},
  pages={
          62-75
        }
}
Mephedrone (4-methylmethcathinone), a constituent of the recreational substances known as "bath salts", is a synthetic cathinone that can produce auditory and visual hallucinations, as well as problematic cardiovascular effects. This study compared the discriminative stimulus effects of mephedrone (0.32-10 mg/kg) with other prototypical drugs of abuse: cocaine (0.56-32 mg/kg), d-amphetamine (0.18-3.2 mg/kg), ketamine (1.8-18 mg/kg), phencyclidine (PCP, 1-5.6 mg/kg), heroin (1-10 mg/kg), 2,5… CONTINUE READING