Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.

@article{Albaugh2012AtypicalAR,
  title={Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents.},
  author={Vance L Albaugh and Thomas C. Vary and Olga Ilkayeva and Brett R. Wenner and Kevin P. Maresca and John L. Joyal and Steven D. Breazeale and Tedd D. Elich and Charles H Lang and Christopher J Lynch},
  journal={Schizophrenia bulletin},
  year={2012},
  volume={38 1},
  pages={
          153-66
        }
}
Patients taking atypical antipsychotics are frequented by serious metabolic (eg, hyperglycemia, obesity, and diabetes) and cardiac effects. Surprisingly, chronic treatment also appears to lower free fatty acids (FFAs). This finding is paradoxical because insulin resistance is typically associated with elevated not lower FFAs. How atypical antipsychotics bring about these converse changes in plasma glucose and FFAs is unknown. Chronic treatment with olanzapine, a prototypical, side effect prone… CONTINUE READING
Highly Cited
This paper has 17 citations. REVIEW CITATIONS

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations