Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro.

@article{Srvri2014AtypicalAI,
  title={Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro.},
  author={Anitta K S{\'a}rv{\'a}ri and Zolt{\'a}n Ver{\'e}b and Iv{\'a}n P. Uray and L{\'a}szl{\'o} F{\'e}s{\"u}s and Zolt{\'a}n Balajthy},
  journal={Biochemical and biophysical research communications},
  year={2014},
  volume={450 4},
  pages={1383-9}
}
Schizophrenia requires lifelong treatment, potentially causing systemic changes in metabolic homeostasis. In the clinical setting, antipsychotic treatment may differentially lead to weight gain among individual patients, although the molecular determinants of such adverse effects are currently unknown. In this study, we investigated changes in the expression levels of critical regulatory genes of adipogenesis, lipid metabolism and proinflammatory genes during the differentiation of primary… CONTINUE READING

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Immunomodulatory effects of clozapine and their clinical implications: what have we learned so far

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