Atypical antipsychotics in bipolar depression: potential mechanisms of action.

  title={Atypical antipsychotics in bipolar depression: potential mechanisms of action.},
  author={Lakshmi N. Yatham and J. M. Goldstein and Eduard Vieta and Charles L. Bowden and Heinz Grunze and Robert M Post and Trisha Suppes and Joseph R. Calabrese},
  journal={The Journal of clinical psychiatry},
  volume={66 Suppl 5},
"Conventional" antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs), bupropion, or serotonin-norepinephrine reuptake inhibitors, are not recommended as monotherapy for bipolar depression. Although they are likely to provide effective symptom relief in combination with mood stabilizers, the risk of precipitating a switch to mania often complicates their use even as combination therapy. Recently, 2 psychotropic medications approved for treating acute mania, olanzapine and… CONTINUE READING


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