Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: An animal model

@article{Guenette2013AtypicalAA,
  title={Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: An animal model},
  author={M. Guenette and Adria Giacca and Margaret K. Hahn and Celine Teo and Loretta Lam and Araba F. Chintoh and Tamara Arenovich and Gary Remington},
  journal={Schizophrenia Research},
  year={2013},
  volume={146},
  pages={162-169}
}
Atypical antipsychotics (AAPs) are associated with several metabolic sequelae including increased risk of type 2 diabetes. Growing evidence points to a direct drug effect of these compounds on glucose homeostasis, independent of weight gain. While the responsible mechanisms have yet to be elucidated, the heterogeneous binding profiles of AAPs likely include receptors involved in glucose metabolism. This study aimed to clarify weight-gain independent mechanisms of AAP-induced alterations in… Expand
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