Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: An animal model

@article{Guenette2013AtypicalAA,
  title={Atypical antipsychotics and effects of adrenergic and serotonergic receptor binding on insulin secretion in-vivo: An animal model},
  author={M. Guenette and Adria Giacca and Margaret K. Hahn and Celine Teo and Loretta Lam and Araba F. Chintoh and Tamara Arenovich and Gary Remington},
  journal={Schizophrenia Research},
  year={2013},
  volume={146},
  pages={162-169}
}

Impact of Muscarinic M 3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients : A Case-Controlled Study

TLDR
Exposure to AD_antaM3 was associated with the development of type 2 diabetes mellitus in patients using antidepressants with and without M3 muscarinic receptor antagonism, suggesting a moderately increased risk of T2DM among antidepressant users.

Antipsychotic Drugs: From Receptor-binding Profiles to Metabolic Side Effects

TLDR
Emerging evidence suggests that antipsychotics have different liabilities to induce obesity, diabetes and dyslipidemia, however this diversity cannot be explained merely by drugs’pharmacodynamic profiles, highlighting the need for further research.

Impact of Muscarinic M3 Receptor Antagonism on the Risk of Type 2 Diabetes in Antidepressant-Treated Patients: A Case-Controlled Study

TLDR
Exposure to AD_antaM3 was associated with the development of T2DM among antidepressant users, and this association was dose dependent and significant for patients who were in the younger age group (<45 years at the end of follow-up), were female and had no co-morbidity.

Second-Generation Antipsychotics and Dysregulation of Glucose Metabolism: Beyond Weight Gain

TLDR
An outlook on current research about the metabolic disturbances provoked by SGAs is given, with a particular focus on whole-body glucose homeostasis disturbances induced independently of AIWG, lipid dysregulation or adipose tissue disturbances.

Antipsychotics and glucose metabolism: how brain and body collide.

Since the serendipitous discovery of the first antipsychotic (AP) drug in the 1950s, APs remain the cornerstone of treatment for schizophrenia. A shift over the past two decades away from

Mechanism 1 : Insulin Resistance Due to Direct Effect of Antipsychotics

TLDR
Effective prevention of APD-induced diabetes may need an integrated approach to combat various effects of APDs on multiple pathways, which could be mediated by multiple mechanisms.

Effects of antipsychotic medications on appetite, weight, and insulin resistance.

  • C. Deng
  • Psychology, Medicine
    Endocrinology and metabolism clinics of North America
  • 2013

Cyclic AMP and calcium signaling are involved in antipsychotic-induced diabetogenic effects in isolated pancreatic β cells of CD1 mice

TLDR
AP-induced alterations in the cAMP and Ca2+ signaling pathways can play a significant role in their diabetogenic potential.

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TLDR
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TLDR
Findings indicate that SGAs can cause acute derangements in glucose metabolism that are not caused by a direct induction of insulin resistance but act via an increase in glucagon secretion and thus stimulation of hepatic glucose production.

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TLDR
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