Atypical antipsychotics and dopamine D(1) receptor agonism: an in vivo experimental study using core temperature measurements in the rat.

@article{Oerther2000AtypicalAA,
  title={Atypical antipsychotics and dopamine D(1) receptor agonism: an in vivo experimental study using core temperature measurements in the rat.},
  author={Sandra Claudine Oerther and Sven Ahlenius},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 2},
  pages={731-6}
}
The study objectives were to examine the effects of the atypical antipsychotic drugs olanzapine, risperidone, and quetiapine on core temperature in the rat in relation to such effects produced by clozapine and to compare possible in vivo intrinsic efficacy of olanzapine, risperidone, and quetiapine at dopamine (DA) D(1) receptors with such effects previously shown for clozapine. Core temperature measurements were made in adult male Wistar rats maintained under standard laboratory conditions… CONTINUE READING

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