Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.

@article{CanfrnDuque2013AtypicalAA,
  title={Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.},
  author={Alberto Canfr{\'a}n-Duque and Mar{\'i}a Emilia Casado and Oscar Meruvia Pastor and Jana S{\'a}nchez-Wandelmer and Gema de la Pe{\~n}a and Milagros Lerma and Paloma Mariscal and Franz Bracher and Miguel Angel Lasunci{\'o}n and Rebeca Busto},
  journal={Journal of lipid research},
  year={2013},
  volume={54 2},
  pages={310-24}
}
Haloperidol, a typical antipsychotic, has been shown to inhibit cholesterol biosynthesis by affecting Δ(7)-reductase, Δ(8,7)-isomerase, and Δ(14)-reductase activities, which results in the accumulation of different sterol intermediates. In the present work, we investigated the effects of atypical or second-generation antipsychotics (SGA), such as clozapine, risperidone, and ziprasidone, on intracellular lipid metabolism in different cell lines. All the SGAs tested inhibited cholesterol… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 23 extracted citations

Effect of psychotropic drug treatment on sterol metabolism.

Schizophrenia research • 2017
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…