Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.

  title={Atypical antipsychotics alter cholesterol and fatty acid metabolism in vitro.},
  author={Alberto Canfr{\'a}n-Duque and Mar{\'i}a Emilia Casado and Oscar Meruvia Pastor and Jana S{\'a}nchez-Wandelmer and Gema de la Pe{\~n}a and Milagros Lerma and Paloma Mariscal and Franz Bracher and Miguel Angel Lasunci{\'o}n and Rebeca Busto},
  journal={Journal of lipid research},
  volume={54 2},
Haloperidol, a typical antipsychotic, has been shown to inhibit cholesterol biosynthesis by affecting Δ(7)-reductase, Δ(8,7)-isomerase, and Δ(14)-reductase activities, which results in the accumulation of different sterol intermediates. In the present work, we investigated the effects of atypical or second-generation antipsychotics (SGA), such as clozapine, risperidone, and ziprasidone, on intracellular lipid metabolism in different cell lines. All the SGAs tested inhibited cholesterol… CONTINUE READING


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