Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.

@article{Kapur2001AtypicalAN,
  title={Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.},
  author={Shitij Kapur and Gary J. Remington},
  journal={Annual review of medicine},
  year={2001},
  volume={52},
  pages={503-17}
}
"Atypical" antipsychotics represent a new generation of antipsychotics with a significantly lower incidence of extrapyramidal side effects (EPS), as well as little or no effect on prolactin elevation. These advantages constitute a major improvement in the treatment of patients with schizophrenia. The exact mechanisms that make these drugs atypical is not clear. However, a preferential action on serotonin 5-HT2 or D4 receptors, or a more rapid dissociation from the dopamine D2 receptor, may… CONTINUE READING