Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles
@article{Nasrallah2008AtypicalAM, title={Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles}, author={Henry A. Nasrallah}, journal={Molecular Psychiatry}, year={2008}, volume={13}, pages={27-35} }
Atypical antipsychotic drugs offer several notable benefits over typical antipsychotics, including greater improvement in negative symptoms, cognitive function, prevention of deterioration, and quality of life, and fewer extrapyramidal symptoms (EPS). However, concerns about EPS have been replaced by concerns about other side effects, such as weight gain, glucose dysregulation and dyslipidemia. These side effects are associated with potential long-term cardiovascular health risks, decreased…
532 Citations
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References
SHOWING 1-10 OF 97 REFERENCES
A review of the effect of atypical antipsychotics on weight
- Psychology, MedicinePsychoneuroendocrinology
- 2003
Metabolic Findings From the CATIE Trial and Their Relation to Tolerability
- Psychology, MedicineCNS Spectrums
- 2006
The CATIE results show that important distinctions exist among currently available atypical antipsychotics, and Physicians should be aware of the propensity of these drugs to increase the risks of cardiovascular disease and diabetes in treated patients and tailor individual treatment decisions accordingly.
Side effects of atypical antipsychotics: extrapyramidal symptoms and the metabolic syndrome.
- Medicine, PsychologyHarvard review of psychiatry
- 2006
It is concluded that atypical antipsychotics continue to have notable risks of EPS, particularly akathisia, and that these agents also appear to increase the risk of the metabolic syndrome, though this effect seems most marked with clozapine and olanzapine.
Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes.
- Medicine, PsychologyMethods and findings in experimental and clinical pharmacology
- 2005
This study provides the first direct evidence to indicate that antipsychotic agents with high binding affinity to the muscarinic M3 receptor are associated with an elevated risk for type 2 diabetes.
Second-Generation (Atypical) Antipsychotics and Metabolic Effects
- Medicine, PsychologyCNS drugs
- 2005
There is no evidence at this time to suggest that ziprasidone and aripiprazole treatment are associated with an increase in risk for diabetes, dyslipidaemia or other adverse effects on glucose or lipid metabolism, but case reports tentatively suggest that substantial weight gain or obesity may not be a factor in up to one-quarter of cases of new-onset diabetes.
Differential metabolic effects of antipsychotic treatments
- Psychology, MedicineEuropean Neuropsychopharmacology
- 2006
Genetic dissection of atypical antipsychotic-induced weight gain: novel preliminary data on the pharmacogenetic puzzle.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2001
Although in its infancy, psychiatric pharmacogenetics will in the future aid clinical practice in the prediction of response and side effects, such as antipsychotic-induced weight gain, and minimize the current "trial and error" approach to prescribing.
Pharmacology of the atypical antipsychotic remoxipride, a dopamine D2 receptor antagonist.
- PsychologyCNS drug reviews
- 2001
In animals, remoxipride has minimal cataleptic effects at doses that block dopamine agonist-induced hyperactivity and these findings are predictive of antipsychotic activity with a low likelihood of extrapyramidal symptoms.
Effects of atypical antipsychotics on weight and serum lipid levels.
- Medicine, PsychologyThe Journal of clinical psychiatry
- 2001
An understanding of appropriate monitoring for metabolic adverse effects is important for those who prescribe atypical antipsychotics, as is a working knowledge of behavioral and pharmacologic treatments for weight gain and hyperlipidemia.
Hyperglycemia associated with the use of atypical antipsychotics.
- Medicine, PsychologyThe Journal of clinical psychiatry
- 2001
These studies indicate that hyperglycemia is not dose dependent, is reversible on cessation of treatment with clozapine or olanzapine, and reappears on reintroduction of these therapies.