Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles

@article{Nasrallah2008AtypicalAM,
  title={Atypical antipsychotic-induced metabolic side effects: insights from receptor-binding profiles},
  author={Henry A. Nasrallah},
  journal={Molecular Psychiatry},
  year={2008},
  volume={13},
  pages={27-35}
}
  • H. Nasrallah
  • Published 2008
  • Psychology, Medicine
  • Molecular Psychiatry
Atypical antipsychotic drugs offer several notable benefits over typical antipsychotics, including greater improvement in negative symptoms, cognitive function, prevention of deterioration, and quality of life, and fewer extrapyramidal symptoms (EPS). However, concerns about EPS have been replaced by concerns about other side effects, such as weight gain, glucose dysregulation and dyslipidemia. These side effects are associated with potential long-term cardiovascular health risks, decreased… 
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532 Citations

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Paliperidone Extended-Release: Safety and Tolerability from a Metabolic Profile Perspective

The ER formulation of paliperidone may offer potential advantages over atypical antipsychotics such as risperidone, particularly with regard to side effects and compliance, but comparative studies are needed.

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Mechanism of Action of Atypical Antipsychotic Drugs in Mood Disorders

The neural mechanisms of currently existing atypical antipsychotic drugs and putative antipsychotics currently being investigated in preclinical and clinical studies are presented and how these relate to their effectiveness in mood disorders such as depression, anxiety, and post-traumatic stress disorder are presented.

Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia

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Unraveling the Mechanisms Underlying Olanzapine-Induced Insulin Resistance

The direct effects of second-generation AAPs on insulin resistance and postprandial gut hormone profiles following a mixed meal are examined and it is found that weight gain is secondary to weight gain in AAP-associated metabolic impairments.

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Chapter 6 - Antipsychotic drugs

...

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