Atypical antidopaminergic properties of CI-686: A potential antipsychotic agent


The effects of the antipsychotic/antidepressant drug CI-686 on apomorphine- and amphetamine-induced stereotypies, dopamine metabolism, neuroleptic binding, and serum prolactin levels were determined. CI-686 displayed profiles of activity in each of these systems that differs markedly from those of other antipsychotics. CI-686's unique preclinical profile suggests a mechanism of action other than dopamine antagonism which could have implications regarding current thinking on the pathophysiology of schizophrenia.

DOI: 10.1007/BF00431984

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@article{Stanley1979AtypicalAP, title={Atypical antidopaminergic properties of CI-686: A potential antipsychotic agent}, author={Michael Stanley and John P. Rotrosen and Nancy Sculerati and Samuel Gershon and Cynthia M . Kuhn and Bruce M. Cohen}, journal={Psychopharmacology}, year={1979}, volume={66}, pages={23-27} }