Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

@inproceedings{Rangaraju2015AtypicalAE,
  title={Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response},
  author={Sunitha Rangaraju and Gregory M. Solis and Sofia I. Andersson and Rafael L. Gomez‐Amaro and Rozina Kardakaris and Caroline D. Broaddus and Alexander B. Niculescu and Michael Petrascheck},
  booktitle={Aging cell},
  year={2015}
}
Oxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by… CONTINUE READING

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