Atypical anti-schizophrenic drugs prevent changes in cortical <ce:italic>N</ce:italic>-methyl-<ce:small-caps>d</ce:small-caps>-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups

@article{Anastasio2008AtypicalAD,
  title={Atypical anti-schizophrenic drugs prevent changes in cortical <ce:italic>N</ce:italic>-methyl-<ce:small-caps>d</ce:small-caps>-aspartate receptors and behavior following sub-chronic phencyclidine administration in developing rat pups},
  author={Noelle C Anastasio and Kenneth M. Johnson},
  journal={Pharmacology Biochemistry and Behavior},
  year={2008},
  volume={90},
  pages={569-577}
}
We sought to determine the relationship between phencyclidine (PCP)-induced alterations in behavior and NMDAR expression in the cortex by examining the effect of anti-schizophrenic drug treatment on both. Sprague-Dawley rat pups were pretreated with risperidone or olanzapine prior to treatment with PCP on postnatal day 7 (PN7) or sub-chronically on PN7, 9, and 11. Pre-pulse inhibition (PPI) of acoustic startle was measured on PN24-26 and following a challenge dose of 4 mg/kg PCP, locomotor… CONTINUE READING
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