Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies

@inproceedings{Muellenbeck2013AtypicalAC,
  title={Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies},
  author={Matthias F. Muellenbeck and Beatrix Ueberheide and B Amulic and Alexandra Epp and David Fenyő and Christian E. Busse and Meral Esen and Michael Theisen and Benjamin Mordm{\"u}ller and Hedda Wardemann},
  booktitle={The Journal of experimental medicine},
  year={2013}
}
Antibodies can protect from Plasmodium falciparum (Pf) infection and clinical malaria disease. However, in the absence of constant reexposure, serum immunoglobulin (Ig) levels rapidly decline and full protection from clinical symptoms is lost, suggesting that B cell memory is functionally impaired. We show at the single cell level that natural Pf infection induces the development of classical memory B cells (CM) and atypical memory B cells (AtM) that produce broadly neutralizing antibodies… CONTINUE READING