Atypical and Conventional Antipsychotic Drugs in Treatment-Naive First-Episode Schizophrenia: A 52-Week Randomized Trial of Clozapine Vs Chlorpromazine

@article{Lieberman2003AtypicalAC,
  title={Atypical and Conventional Antipsychotic Drugs in Treatment-Naive First-Episode Schizophrenia: A 52-Week Randomized Trial of Clozapine Vs Chlorpromazine},
  author={Jeffrey A. Lieberman and Michael Phillips and Hongbin Gu and Scott T Stroup and Peiyan Zhang and Lan Kong and Zhongfu Ji and Gary Koch and Robert M. Hamer},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={995-1003}
}
The purported advantages of second-generation or ‘atypical’ antipsychotics relative to first-generation antipsychotics have not been examined in patients with a first episode of schizophrenia. This flexible-dose study examined efficacy and safety in a randomized, double-blind, 52-week trial, comparing chlorpromazine (CPZ) and clozapine (CLZ) in treatment naive patients experiencing their first episode of schizophrenia. In all, 160 inpatients with first-episode schizophrenia or schizophreniform… CONTINUE READING
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