Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration

@article{Josephs2006AtypicalPS,
  title={Atypical Progressive Supranuclear Palsy With Corticospinal Tract Degeneration},
  author={K. Josephs and O. Katsuse and D. Beccano-Kelly and W. Lin and R. Uitti and Y. Fujino and B. Boeve and M. Hutton and Matthew C. Baker and D. Dickson},
  journal={Journal of Neuropathology and Experimental Neurology},
  year={2006},
  volume={65},
  pages={396-405}
}
  • K. Josephs, O. Katsuse, +7 authors D. Dickson
  • Published 2006
  • Medicine, Biology
  • Journal of Neuropathology and Experimental Neurology
  • Progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), sporadic multisystem tauopathy, and some forms of frontotemporal dementia with Parkinsonism linked to chromosome 17 are characterized by neuronal and glial lesions accumulating tau protein containing 4 conserved repeats in microtubule-binding domain (4R tau). Corticospinal tract degeneration is not a common feature of 4R tauopathies. Our objective was to describe 12 cases with pathologic features similar to those of PSP but… CONTINUE READING
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