Atypical PKC Phosphorylates PAR-1 Kinases to Regulate Localization and Activity

@article{Hurov2004AtypicalPP,
  title={Atypical PKC Phosphorylates PAR-1 Kinases to Regulate Localization and Activity},
  author={Jonathan B. Hurov and Janis L Watkins and Helen Piwnica-Worms},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={736-741}
}
The establishment and maintenance of cellular polarity are essential biological processes that must be maintained throughout the lifetime of eukaryotic organisms. The Par-1 protein kinases are key polarity determinants that have been conserved throughout evolution. Par-1 directs anterior-posterior asymmetry in the one-cell C. elegans embryo and the Drosophila oocyte. In mammalian cells, Par-1 may regulate epithelial cell polarity. Relevant substrates of Par-1 in these pathways are just being… CONTINUE READING
Highly Influential
This paper has highly influenced 17 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 131 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Similar Papers

Loading similar papers…