• Corpus ID: 53414709

Atypical Fibroxanthoma : A Case Report and Literature Review

@inproceedings{Fisher2017AtypicalF,
  title={Atypical Fibroxanthoma : A Case Report and Literature Review},
  author={Jacqueline C. Fisher and Megan Jones and Daniel S. Hurd},
  year={2017}
}
Atypical fibroxanthoma (AFX) is a rare, rapidly growing mesenchymal neoplasm that often presents on sun-exposed head and neck regions of older individuals. The diagnosis relies on knowledge of its clinical and histological features combined with immunohistochemistry markers used primarily to exclude other cutaneous neoplasms that may share a similar clinical presentation. Current treatment guidelines recommend wide local excision or Mohs micrographic surgery to prevent local recurrence and, on… 
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Figures and Tables from this paper

An Atypical Fibroxanthoma and Intradermal Nevus Collision Tumor-Potential for Misdiagnosis.
TLDR
This unusual collision tumor between AFX and an intradermal nevus highlights the important role immunohistochemistry plays in avoiding the misdiagnosis and potential overtreatment of benign or low-grade lesions, and in identifying potential mimickers.

References

SHOWING 1-10 OF 18 REFERENCES
Atypical Fibroxanthoma: A Review of the Literature
TLDR
The current literature on AFX pertaining to epidemiology, pathogenesis and etiology, clinical presentation, histology, immunohistochemistry, prognosis and follow-up, and treatment is reviewed.
Atypical Fibroxanthoma in a 115-Year-Old Patient
TLDR
The aim of this report is to highlight the strict criteria involved in diagnosing AFX and to discuss the differential diagnosis of this benign lesion in contradistinction to the former definition as well as histopathological diagnosis, which might be of interest to clinicians.
Atypical Fibroxanthoma: Review of the Literature and Summary of 13 Patients Treated with Mohs Micrographic Surgery
  • M. Seavolt, M. McCall
  • Medicine
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
  • 2006
TLDR
There is no clear recommendation on treatment in the medical literature, but there have been a few reports of treatment with Mohs micrographic surgery (MMS), which showed a lower local recurrence rate than with excision.
Atypical Fibroxanthoma - Histological Diagnosis, Immunohistochemical Markers and Concepts of Therapy.
TLDR
Adequately treated, AFX has an excellent prognosis, but long-term follow-up is recommended due to the potential for aggressive behavior, and a well-selected panel of immunohistochemical markers is necessary to establish AFX diagnosis with sufficient certainty.
Atypical fibroxanthoma and malignant fibrous histiocytoma.
Atypical Fibroxanthoma
TLDR
Atypical fibroxanthoma (AFX), as well as MFH (malignant fibrous histiocytoma), is a fibrohistiocytic lesion with myofibroblastic differentiation, which is considered to be a different lesion from MFH.
Atypical fibroxanthoma: a selective review.
TLDR
A review of atypical fibroxanthoma with special emphasis on the histomorphology, subtypes, immunophenotypic profile, and discussion of differential diagnosis is presented.
Localized Cutaneous Metastases from an Atypical Fibroxanthoma
TLDR
Metastases attributed to atypical fibroxanthoma are rare, and many prior reports may have actually been malignant fibrous histiocytoma, spindle cell melanoma, orSpindle cell squamous carcinoma.
More Than 2 Decades of Treating Atypical Fibroxanthoma at Mayo Clinic: What Have We Learned From 91 Patients?
TLDR
Total microscopic margin control using MMS was the most effective means of treating AFX, based on a review of cases treated at Mayo Clinic.
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