Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.


RT-PCR detects chimeric BCR-ABL mRNA in approximately 25% of adult acute lymphoblastic leukemia (ALL) cases. Minor breakpoint transcripts (e1a2) are found in about 70% of positive cases and major breakpoint transcripts (e13a2, e14a2) in about 30% of cases. However, other atypical transcripts are sometimes observed. We report experience gained in the GMALL Study Group and identified 8 BCR-ABL-positive adult ALL cases with such atypical transcripts: 5 with e1a3, 2 with e13a3 (b2a3), and 1 with e6a2. This corresponds to a prevalence of 1-2% of all BCR-ABL-positive cases. The clinical courses are reported and diagnostic proposals are made.

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@article{Burmeister2007AtypicalBM, title={Atypical BCR-ABL mRNA transcripts in adult acute lymphoblastic leukemia.}, author={Thomas Burmeister and Stefan Schwartz and Almut Taubald and Edgar Jost and Thomas Lipp and Folker Schneller and Helmut Diedrich and Henrike Thomssen and Ulrich Mey and Jan Eucker and Harald Rieder and Nicola Goekbuget and Dieter Hoelzer and Eckhard Thiel}, journal={Haematologica}, year={2007}, volume={92 12}, pages={1699-702} }