Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104

Abstract

Hsp104, a yeast protein-remodeling factor of the AAA+ (ATPases associated with various cellular activities) superfamily, and its homologs in bacteria and plants mediate cell recovery after severe stress by disaggregating denatured proteins through a poorly understood mechanism. Here, we present cryo-electron microscopy maps and domain fitting of Hsp104… (More)
DOI: 10.1016/j.cell.2007.10.047

Topics

Cite this paper

@inproceedings{Wendler2007AtypicalAS, title={Atypical AAA+ Subunit Packing Creates an Expanded Cavity for Disaggregation by the Protein-Remodeling Factor Hsp104}, author={Petra Wendler and James Shorter and Celia Plisson and Anil Cashikar and Susan Lindquist and Helen R Saibil}, booktitle={Cell}, year={2007} }