Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. An experimental stereological investigation.

@article{Marcussen1990AtubularGI,
  title={Atubular glomeruli in cisplatin-induced chronic interstitial nephropathy. An experimental stereological investigation.},
  author={Niels Marcussen},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={1990},
  volume={98 12},
  pages={1087-97}
}
  • Niels Marcussen
  • Published 1990 in
    APMIS : acta pathologica, microbiologica, et…
In two previous studies on chronic renal failure in humans as well as in experimental animals a large number of glomeruli were found not to be connected to proximal tubules (atubular). Using unbiased stereological methods the purpose of the present study was to investigate and quantitate various renal structures, including the presence or absence of atubular glomeruli, in chronic renal failure induced by cisplatin. After administration of cisplatin to rats for ten weeks, the left kidney was… CONTINUE READING

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The presence of atubular glomeruli and the absence of compensatory hypertrophy of the remaining nephrons might be responsible for the reduction in kidney function in several chronic interstitial renal diseases .
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