Atubular glomeruli in a rat model of polycystic kidney disease.

  title={Atubular glomeruli in a rat model of polycystic kidney disease.},
  author={George A. Tanner and Marcus A Tielker and Bret A. Connors and Carrie L. Phillips and Judith A Tanner and Andrew P. Evan},
  journal={Kidney international},
  volume={62 6},
BACKGROUND Autosomal-dominant polycystic kidney disease (ADPKD) is associated with a progressive decline in glomerular filtration rate (GFR) that often leads to end-stage renal disease. The basis for this decline in GFR is poorly understood. METHODS Glomeruli in heterozygous Han:SPRD rats with ADPKD and their normal litter mates were studied by light microscopy, using serial sectioning techniques. The connections of the renal corpuscles to proximal tubules were classified as normal, atrophied… CONTINUE READING
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